Published date: 20 April 2020

Awarded contract - This means that the contract has been awarded to a supplier.


Closing: 1 October 2019

Contract summary

Industry

  • Research and development services and related consultancy services - 73000000

Location of contract

BS8 1QU

Value of contract

£0

Procurement reference

tender_229808/851179

Published date

20 April 2020

Closing date

1 October 2019

Contract start date

1 November 2019

Contract end date

31 March 2020

Contract type

Service contract

Procedure type

Single tender action (below threshold)

A direct contract with a single supplier, without competition.

This procedure can be used for procurements below the relevant contract value threshold.

Contract is suitable for SMEs?

Yes

Contract is suitable for VCSEs?

No

Description

Canine cutaneous and renal glomerular vasculopathy (CRGV and sometimes known as 'Alabama rot') in the UK first appeared in 2012, with 4 cases presenting to a Anderson Moores from practices around the New Forest, Hampshire with acute kidney injury (AKI) and skin lesions. The numbers of cases and geographical distribution of the disease have in the main increased year on year, with 190 cases now reported. The disease is normally characterised by the initial appearance of skin lesions on the limbs +/- face and body. Some dogs then go on to develop acute deterioration of kidney function and death. On post mortem blood vessels are seen to be blocked by thrombi (clots).

The cause of the disease is unknown, despite investigation. Tests undertaken include investigation for E.coli (given some similarities to human haemolytic uremic syndrome), Circovirus, pan viral metagenomics and bacterial 16S probes, heavy metals and ethylene glycol poisoning. Leptospira has been investigated as a cause, and although presence of this organism was high in cases, results couldn't indicate a causative link.
Despite the extensive investigations already undertaken, a few bacterial causes remain possible based upon experimental results or pathological findings. Toxigenic bacteria have not been found in the kidneys, but this does not rule out their presence in the skin lesions, with local production of toxins into the circulation causing subsequent kidney injury. Shiga toxigenic E. coli were hypothesised to cause similar disease in the USA with kidney injury. Aeromonas hydrophilia causes similar skin lesions in fish and amphibians with subsequent kidney failure, as well as disease in humans, and are also toxigenic, with toxin production in limbs causing organ injury. Leptospira were unusually prevalent in cases and can cause kidney injury.

Without an analysis of cases vs healthy animals it is impossible to confirm the likely association of these bacteria (Aeromonas, E.coli and Leptospira

More information

Attachments

Links

Additional text

Please note that Defra procurement uses an E-tendering system for Procurement activities. This is currently provided by Bravo Solutions. To access appropriate tendering and contractual documents, please access the E-Tendering portal at https://defra.bravosolution.co.uk";, ensuring that your registration includes "Defra". If you have any problems with this system, please contact Bravo on their telephone helpline number 0800 368 4850 or by emailing them at help@bravosolution.co.uk. "

Award information

Awarded date

10 February 2020

Contract start date

1 November 2019

Contract end date

31 March 2020

Total value of contract

£25,000

This contract was awarded to 1 supplier.

University of Bristol,

Address

Beacon House,Queens Road,Bristol,BS8 1QU

Reference

No reference - other

Supplier is SME?

No

Supplier is VCSE?

No

About the buyer

Contact name

Ajay Tyagi

Address

17 Nobel House
London
SW1P 3JR
England

Telephone

00

Email

Ajay.Tyagi@defra.gov.uk